LiNbO3光纤型行波光调制器的有限元分析

提出一种光调制器———L iNbO3光纤型行波光调制器,在结构上与传统的L iNbO3波导型调制器不同,它用L iNbO3光纤代替L iNbO3波导传输光载波,衬底则由低介电常数的S iO2取代高介电常数的L iNbO3.采用有限元法对厚的对称电极进行分析,得到调制器微波等效折射率以及等效特征阻抗随电极宽度、厚度、两电极间距以及缓冲层厚度4个参数的变化规律.分析结果表明,与传统L iNbO3波导型调制器相比,L iNbO3光纤型行波光调制器在相速匹配方面表现出极大优越性,若仅考虑相速匹配,理论上可得到高达300 GHz.m的带宽长度积,远大于传统的波导型调制器的1~10 GHz.m的限制,彻底解决了一般L iNbO3波导型行波光调制器在相速匹配方面的困难,极大地提高了调制带宽,具有很大的应用前景.     

声光双稳系统浑沌产生实验及其主频模式分析

介绍了声光双稳系统浑沌产生实验。从理论上推导出主频模式的解析公式，并对数值计算结果进行付立叶分析，给出寻找浑沌的途径及其理论依据。     

Cellular models for the detection and evaluation of drugs that modulate human phagocyte activity

Summary Simple testing models have been developed for the evaluation of chemical or biological compounds that modulate the activity of human phagocytes. Human neutrophils from buffy coats of donor blood are used. They are stimulated with receptor agonists, and the effects of test compounds on exocytosis of different enzymes, the generation of superoxide (respiratory burst), and cytotoxicity are quantified. All assays are performed in microtiter plates and the responses are evaluated by multi-well photometry or fluorimetry. The models are apt to detect compounds acting on phagocytes as agonists or antagonists, signal transduction activators or inhibitors and primers of agonist responses, and to assess cytotoxic effects.     

Sudakov压低的Balitsky-Kovchegov方程在重夸克产生中的应用研究

在色偶极子模型框架下,该文首次采用Sudakov压低的Balitsky-Kovchegov演化方程研究HERA能区粲夸克和底夸克的产生.通过数值方法求解微分积分形式的Balitsky-Kovchegov方程,获取Sudakov压低的散射振幅,结合虚光子劈裂成正反夸克对的波函数,开展电子-质子深度非弹性散射中重夸克产生约化截面研究.为了避免过度拟合,该文将前期研究中获得的模型参数直接应用于描述粲夸克和底夸克的产生,不再对粲夸克和底夸克的约化截面数据进行单独拟合,结果显示Sudakov压低了的散射振幅较领头阶散射振幅给出了更符合实验测量的描述效果,由此表明Sudakov压低效应对重夸克的产生有着重要的作用.     

Development of a functional cell-based HTS assay for identification of NKCC1-negative modulators

Na–K–Cl cotransporter 1(NKCC1) cotransports Na+, K+, and Cl-ions across the plasma membrane into cells. Accumulation of Cl-ions in dorsal root ganglion neurons induces depolarizing GABAA receptors, which mediate presynaptic inhibition and filtration of sensory noise. The activity of the Na–K–Cl cotransporter is modulated by high-dose loop diuretics, such as furosemide and bumetanide. To identify NKCC1 modulators, we developed a functional cell-based assay feasible for highthroughput screening(HTS), in which the activity of NKCC1 was detected by a BTC-AM dye-based thallium transportation assay. We demonstrated that the influx of Tl?was mediated by NKCC1, which required the existence of Cl-ions and could be inhibited by bumetanide and furosemide. Our results demonstrated that the assay was stable, reproducible, and suitable for HTS of negative modulators for NKCC1.     

基于受激布里渊散射的高精度多微波频率测量

为实现高精度大范围多微波频率测量, 利用双平行马赫曾德尔调制器(dual parallel Mach-Zehnder modulators, DPMZM)分别对未知信号和扫描信号进行抑制载波单边带调制, 并分别作为信号光和泵浦光输入到色散位移单模光纤中, 当两者满足一定的频率关系时, 信号光会得到放大, 通过测量输出光功率值即可估计出待测信号的频率值。该方案利用双阶段受激布里渊散射结构降低了受激布里渊散射增益线宽。另外, 通过设置DPMZM的调制参数, 即可利用低频段的扫描信号实现高频段的频率测量, 降低了方案的实现复杂度。为进一步提高算法精度, 利用测量的光功率值建立幅度比较函数, 通过计算可得频率测量误差, 通过误差修正可提升方案的测频精度。最后, 通过实验仿真证实了方案的有效性, 测量误差为±3 MHz。